Exploration of Forbidden Povarov Processes as a Source of Unexpected Reactivity: A Multicomponent Mannich–Ritter Transformation
Published in Angewandte Chemie International Edition, 2012
Recommended citation: Preciado S., Vicente-García E., Llabrés S., Luque FJ. and Lavilla R. (2012) Angewandte Chemie International Edition. 51, 6874–6877. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201202927
Abstract:
The use of geometrically or electronically restricted imines for Povarov‐type processes does not afford the anti‐Bredt tetrahydroquinolines, but leads instead to highly functionalized structures through novel reaction pathways (see picture; LA=Lewis acid). The exploration of “forbidden” routes constitutes a valuable approach in the search for new multicomponent reactions.
Recommended citation: Preciado S., Vicente-García E., Llabrés S., Luque FJ. and Lavilla R. (2012) Angewandte Chemie International Edition, 51, 6874–6877.